Peripheral artery disease (PAD) is a circulatory problem in which narrowed arteries reduce blood flow. Arteries carry blood from the heart to the extremities. Plaque builds up in those narrow tubes, restricting blood flow as a result.  PAD affects your extremities — usually, your legs —  and the blood flow cannot keep up with the demand.

PAD can cause sharp leg pain and cramping, particularly after exertion. Other signs of PAD include uneven hair and nail growth on legs and body temperature differences in limbs.